Background: Great auricular nerve block provides better postoperative analgesia than systemic analgesics in tympanomastoid surgery, henceforth reduces chances of systemic side effects like nausea and vomiting as systemic analgesics used being minimized. This prospective randomized clinical study was carried out to evaluate the efficacy of great auricular nerve block, to compare the total number of analgesics required in 24 hours period postoperatively and to look for complications if any. Methods: In this prospective randomized clinical study, 60 patients of ASA Grade I or II, aged 18 to 65 years, undergoing tympanomastoid surgery were randomly allocated in Two groups. Group G (n = 30) patients received great auricular nerve block, and Group C (n = 30) as control Group. All patients were premedicated with Inj. Nalbuphine (0.15 mg/kg), and general anesthesia was given using conventional method. In Group G great auricular nerve block was given using 0.25% Inj. bupivacaine 7 ml with Injection Epinephrine 5 μg/ml 1:200000 prior to reversal of general anesthesia.and Group C (Control Group) didn’t receive the block. Results: Duration of postoperative analgesia was 20.67 ± 4.54 hours in Group G and 2.13 ± 4.18 hours in Group C (p < 0.001). Total number of rescue analgesics required in 24 hours in postoperative period less in Group G compared to Group C. Conclusions: The Great auricular nerve block provides prolonged duration of action and decreased number of rescue analgesic in postoperative period for patients posted for mastoidectomy.