Introduction: Endotracheal intubation is the translaryngeal placement of endotracheal tube into the trachea. Hypertension and tachycardia, usually accompany larynogoscopy and tracheal intubation. Aims: A comparative study of attenuation of hemodynamic responses to laryngoscopy and intubation with and without oral clonidine. Materials and Methods: This study was done in Fifty patients were selected for the study with the age group ranging between 20–60 years belonging to ASA Group-I. Patients undergoing elective surgical procedures were included in the study. The fifty patients were randomly divided into Two Groups: Control Group and Study Group. Each Group consisted of 25 patients. Results: Preinduction and postinduction hemodynamic values were significantly lower in study (clonidine) group, when compared with those of control (without clonidine) group. The difference was statistically significant. Conclusions: The stability of heart rate and blood pressure could be achieved by using clonidine 5 ug/kg as a premedicantly useful in management and can prevent instances of ‘alpine anesthesia’(attempt to delineate the role of intraoperative hypotension and blood pressure variability).