Hypoglycemia in neonates is a common clinical problem and is associated with wide variety of disorders. However, its definition, clinical significance, and management remain controversial. Studying the incidence may help to plan the services, identifying the risk factors associated with hypoglycemia, may help in preventing neurological damage due to neonatal hypoglycemia. Aims and Objectives: To study clinical profile of neonatal hypoglycemia. To study the causes responsible for neonatal hypoglycemia. Materials and Methods: All neonates admitted in NICU both Inborn and Outborn were included in the study and BSL less than 40 mg/dl was taken as hypoglycemic. Results: Fifty seven percent of the babies had hypoglycemia, out of which preterm babies had highest percent of hypoglycemia. Septicemia accounted for 65.3% of the hypoglycemic cases. Lethargy was the most common symptom among hypoglycemia. Home delivery also had significant association with hypoglycemia cases. Among the total death of the hypoglycemic babies, HIE III was the most common cause. Lab values well correlated with glucometer readings. Incidence of hypoglycemia was most during the first 3 hours of life.