Background: Hypocalcemia is a known entity in nephrotic syndrome. Does hypercalciuria contribute to this state, is investigated in our study. Aims: To study the urinary calcium excretion during nephrotic range proteinuria and during remission in nephrotic children. Design & Setting: This observational-cohort study was carried out in a tertiary care hospital in Northern India from July 2015 to June 2016. Material & Methods: Eighty consecutive nephrotic patients (aged 2-14 years) with new onset nephrotic syndrome or relapse were enrolled. Eight patients were lost to follow up and 3 were excluded due to addition of calcium to their treatment. Urinary and blood samples of the patients were sent at initial enrollment, at remission and at completion of alternate day therapy. Urinary calcium to urinary creatinine ratio (UCa/UCr) at onset (of patients with initial episode) or relapse (in known cases of nephrotic syndrome) and during remission was compared. Statistical Analysis: Analysis of variances (ANOVA) was applied for comparison among groups showing normal distribution and Kruskal-Wallis Test was used for parameters having non-Gaussian distribution. Results: No statistically significant difference in the value of UCa/UCr was observed during onset/relapse, after remission and after stopping steroid therapy. Conclusion: Urinary calcium excretion does not statistically vary during nephrotic range proteinuria and after it.

Keywords: Calciuria; Relapse; Remission; UCa/UCr ratio.