Introduction: The Quality of Life in Children with Chronic diseases is a crucial, yet often neglected part of child’s overall health. Chronic diseases and their treatment present children and their parents with significant chronic stress that lead to emotional and behavioural problems compromising adherence to treatment. WHO defines Quality of life as an individual perception of their position in life in context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns [1].

Method: Cross-Sectional Study conducted in the Department of Paediatrics, JSS Hospital Mysuru from 1-10-2014 to1-8-2016.60 Children aged 7 to 18 years, suffering from chronic disease since at least 3 months were selected at random. Interviewing was done using 2 Questionnairres namely EQ-5DY administered to children and CPMS Questionnairre given to Parents/Gaurdians, after obtaining valid consent from authorities and Parents. Data was entered in Excel and analysed using SPSS Software.

Results: There was no association between the Socio-Demographic factors and Quality of Life or Psychological issues in the children. In the EQ-5DY Questionnaire, the children who had some pain and discomfort also had significant Psychopathology and P Value being 0.03 was significant. 95% of our population had possible Psychopathology indicating that Mental Health is affected in children suffering from various chronic diseases. Children with seizure disorder had problems in daily activities, had some pain and discomfort and all were worried/sad.

Conclusions: All children with chronic disease, irrespective of age, gender and socio-economic class have high risk for impaired Quality of Life and Mental Health problems.

Keywords: Quality of Life; Chronic Diseases; EQ-5D-Y IS A; Childhood Psychopathology Measurement Schedule (CPMS).