Background: Enteric fever is common waterborne disease in India and poses a therapeutic challenge in children due to emergence of drug resistant organism. Objective: the present study was undertaken to review the changes in antibiotic sensitivity and resistance pattern of almonella typhi in eastern Uttar Pradesh. Methods: The study consisted of 79 clinically and serologically confirmed cases of enteric fever aged 2­15 years from may 2009 to January 2015 and subjected to blood culture and sensitivity. We had not done phage typing of isolated organism. Results: almonella typhi was sensitive to ciprofloxacillin, cefotaxime, ceftriaxone and cefixime in 75%, 72%,71% and 72% respectively and resistant to both ciprofloxacillin and ceftriaxone in 38%. There is declining trend in resistant pattern to amoxicillin, chloramphenicol and cotrimoxazole as observed and reported from same institute in 1996. Conclusion: The drug resistant enteric fever still remains a therapeutic challenge and combination therapy with ceftriaxone and other antimicrobials may be another option.

Keywords: Enteric fever; Salmonella typhi; Sensitivity.