The existence of zoonotic diseases affecting humans and animals have historically been recorded for over hundreds of years. However, factors such as changes in agro-ecological conditions and international commerce, have led to increase in the incidence of disease outbreaks.With the advancement of technology, livestock production has gained an integral position in the national economy, socioeconomic development, poverty alleviation and nutrition supply for human beings. However, with increase in globalization, challenges in maintaining healthy herds of livestock are arising. The major reason behind the emergence/re-emergence of these diseases is the spread of disease-causing pathogens across borders. Such transboundary diseases have the potential to spread rapidly irrespective ofnational borders and can therefore cause serious socioeconomic consequences. Several new transboundary zoonoses emerge, and old diseases re-emerge, exhibiting increased chances for unexpected spread to new regions, often over great distances. These transboundary diseases adversely affect food safety, rural livelihoods, human health and international trade.Also, the interaction of wildlife with humans and other livestock animals have increased the risk of spread of pathogens across boundaries and consequent disease. Minimizing the movement of animals across the borders is essential and prompt practice of quarantine protocol would help reducing many transboundary diseases. Also, it is important to developscientific and risk-based standards which help in facilitating the international trade in animal commodities. The review focuses on the need for ensuring public awareness for transboundary zoonotic diseases, as an emerging disease may go unnoticed as such, unless it is reported to the concerned authority