Fungi are eukaryotic, non-photosynthetic organisms. Most of the fungal organisms are saprophytic or commensals but some are parasitic as well, causing a myriad of diseases in animals and humans. Some of the fungal organisms are of zoonotic significance and hence can be transmitted from animals to humans. Fungal infections are chronic in nature and only few antifungals are available till date. Risk of fungal infection increases if the indivisual is immunocompromised, suffering from metabolic diseases, old aged and is undergoing prolonged antibiotic therapy. Antifungals are drugs aimed to treat fungal infections. These target the fungal cell, cell membrane, metabolism, nucleic acid, growth and divisions. But as fungi are eukaryotic organisms, antifungals aimed to kill the fungal organism can also potentially harm the host cell.