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RFP Indian Journal of Hospital Infection

Volume  1, Issue 2,  July - December 2019, Pages 93-104
 
Review Article

TP53 as a Tumor Suppressor Gene

Mosin S Khan, Roohi Ashraf, Aaliya Shah, Syed Mudassar

Department of Biochemistry, Govt. Medical College, Srinagar and Associated Hospitals, Karan Nagar, Srinagar, Jammu and Kashmir 190010, India. 3Department of Biochemistry, SKIMS Medical College and Hospital, Bemina, Srinagar, Jammu and Kashmir 190018, India. 4Professor and Head, Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir 190011, India.

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Abstract

Recognition of TP53’s prominent role in protection from cancer has boosted a huge amount of scientific reports (around 40000) describing the function of TP53 as a tumour suppressor. Quite an unusual feature of a tumour suppressor was noted – TP53 is point mutated rather than inactivated in cancers and is highly expressed in tumours. Mutation of TP53 gene confers novel oncogenic properties on TP53 protein.
 
Keywords : Cancer; TP53; Tumor suppressor gene; Polymorphism
Corresponding Author : Syed Mudassar