Introduction: Up to 85% of people infected with H. Pylori never experience symptoms or complications. Acute infection may appear as an acute gastritis with abdominal pain or nausea. Where this develops into chronic gastritis, the symptoms, if present, are often those of non-ulcer dyspepsia, stomach pain, nausea, bloating, belching, and sometimes vomiting or black stool. Inflammation of the pyloric antrum is more likely to lead to duodenal ulcers, while inflammation of the corpus is more likely to lead to gastric ulcers and gastric carcinoma. Materials & methods: A retrospective study was done in 310 patients diagnosed to have peptic ulcer disease by upper gastrointestinal endoscopy in Adichunchanagiri Institue of Medical Sciences, B.G. Nagar. The study was from August 2018 to January 2019. All the patients were subjected to upper gastrointestinal endoscopy during which biopsies, each from the antrum and the pathological areas were taken. The two biopsy specimens were sent for routine histopathology and staining with Giemsa stain. The case was taken as H.pylori positive when the histopathological examination was positive. Results: Out of 310 patients, 246 patients were diagnosed to have been infected with H.pylori infection (79.4%). Out of 310, the duodenal ulcer were present in 204 (65.8%) patients, gastric ulcer were present in 88 (28.4%) patients and both duodenal and gastric ulcers were present in 18 (5.8%) patients. Conclusion:In this study, we found that in peptic ulcer disease, H. Pylori was consistently associated. Thus we conclude H. Pylori infection definitely have role in the etiopathogenesis of peptic ulcer disease. The study also gives information that H. Pylori is more common in rural and lower socioeconomic group. Hence, we recommend eradication of the bacteria only in patients positive for the bacterium, who have peptic ulcer disease. Our study implies that H.pylori infection has an overall prevalence of around 79.4% in peptic ulcer patients in our AIMS hospital. Its presence is more with ulcerative dyspepsia patients and its prevalence increases with age.

Keywords: Helicobacter pylori; Peptic Ulcer Disease; Duodenal Ulcer; Gastro-Intestinal Endoscopy.