Background: Hyperbaric Oxygen Therapy (HBO) is an established treatment modality, internationally practiced since a long time ago. International protocols for the practice of hyperbaric oxygen therapy have been established in the United States by the Undersea and Hyperbaric Medical Society and in Europe by the European Committee for Hyperbaric Medicine. In India, HBO seems to be a well-accepted adjunctive treatment for diabetic foot, gas gangrene and post radiation complications. Objective: The main aim of this study is to describe the referral patterns, the different indications and patient population treated at the Prana HBO center, and to describe the protocols followed at the center and determine whether these conform to the standards established by the UHMS. Study Design: A Descriptive cross sectional study (retrospective record review) was performed to realize the aim and objectives of this study. Place of Study: The study was carried out at the Prana HBO Centre, which is owned by the Investigator and located in the Northern parts of Mumbai, in India. Methods: The data was collected from all the patient files, which are stored at the center. TCOM data was also collected from the Centre register which is maintained separately. Observation & Discussion: A total number of 276 patients were treated at the hyperbaric facility during the study period. These individuals received a total of 2,740 individual treatment sessions. An average of 9.928 (SD=F.2) treatment sessions were thus provided to each patient. One patient received 80 treatment sessions, skewing the data. The median number of treatment sessions was 10, with an inter-quartile range of 5 - 10. TCOM was carried out on diabetic foot patients (67.8%) and in non-healing wound (22.2%). Chronic venous ulcers and compromised skin graft cases TCOM was not advised either by the treating doctor or the wound was so big that, TCOM was not possible. Conclusions: Indian perspective requires Standard HBOT facility and registry reporting as a part of healthcare reform to facilitate the acquisition of real-world data for HBOT comparative effectiveness studies, with matched cohorts. Keywords: Hyperbaric oxygen therapy; India; Clinical and basic research.