AbstractThrough the ages, Forensic Medicine has evolved as a highly analytical science involving keen powers of observation and deduction. In my study , I have talked about age old mysteries , mysteries that have baffled humanity since centuries and how they were ultimately solved using the new techniques of Forensic Medicine and Toxicology. I have included the mystery of the death of egyptian king Tutankhamun , the mysterious death of Napolean Bonaparte and the mystery of the missing russian princess - Anastasia. The new advancements in Forensic Medicine and Toxicology have helped us unravel the puzzle and have succeeded in shedding some light on the truth.