Fluoroquinolones are widely used antimicrobial agents for the treatment of various infections. These agents produce clinically significant excitatory side effects on central nervous system. and are attributed to the inhibition of g-aminobutyricacid (GABA) binding to the GABA- A receptor. GABA is involved in the regulation of dopaminergic neuronal activity within the forebrain and nigro straiatal system. Evidence indicate that the GABA-mimetic drugs potentiate neuroleptic-induced catalepsy. In this context as there are no evidence about the effects of fluroquinolones on haloperidol induced catalepsy, the present study was undertaken to evaluate the effects of ciprofloxacin, a fluroquinolone on haloperidol induced catalepsy in mice.