Globally, breast cancer is the most common neoplasm in women. Late presentation contributes to poor outcome and high fatality rate. Most successful approach to decrease mortality due to breast cancer is the application of secondary prevention which includes Breast Self-Examination (BSE), Clinical Breast Examination (CBE) and Mammography. Mammography is expensive and technology driven. BSE is easy, cheap and self monitored. Therefore, it is important to empower women on the BSE as a primary tool for screening especially among the high risk group in developing countries. Despite the effectiveness of BSE in reducing mortality, research findings indicate the screening rates remain low. The foremost barriers being forgetfulness, lack of time, ignorance, fear and anxiety and low level of education. The health care workers play an important role in communicating health behaviours to the public hence it is important to assess the level of knowledge regarding the BSE as well as their attitude and practice towards it.*Methodology A sample size of 200 randomly selected female health care workers (HCW) (107 doctors & 93 nurses) was taken. A selfadministered, pre-tested, structured, close ended questionnaire was used to assess the knowledge of breast cancer, breast self-examination and responses to the practice of breast self examination by the study subjects.