Abstract Interpleural and paravertebral blocks are indicated for providing intra operative and post operative analgesia in unilateral surgeries of the chest and abdomen including breast surgery. The aim of this prospective randomized study was to evaluate the intra operative analgesic requirement, haemodynamic parameters, efficacy and duration of postoperative analgesia and the possibility of home readiness of patients receiving paravertebral block or interpleural block as an adjuvant to general anaesthesia.