Patients admitted for breast cancer surgery were studied. Patients received Tab. Etoricoxib 90mg per orally 1hr prior to surgery. General anesthesia was induced using Propofol and Fentanyl. Subjects were randomized to receive, in a double blind manner, either by Inj. Dexamethasone 16mg (Group D) or a placebo (saline-Group P). Both study groups were administered 20-30 ml Bupivacaine 0.25% as incisional wound infiltration at the end of surgery. Post operative pain, nausea and vomiting were evaluated in all subjects using a questionnaire in the immediate post operative period, 24 and 72 hrs post surgery