Study of factors responsible for crisis of Sickle Cell Anemia and Its medical management at Dr.P.D.M.Medical College,Amravati.Introduction –1. In the world’s population 5% population carries genes responsible forHemoglobinopathies.2. Sickle cell anemia is a group of heredieatary disease characterized bytransformation of red cell into sickle shape on deoxygenating. It’s commonin people whose ancestors come from Sub Saharan Africa, India, countries.Cyprus is a country where Sickle Cell Anemia was very common butbecause of counseling its prevalence has been reduced almost to zero.3. Poor prenatal diagnostic facilities are available to detect Sickle CellAnemia and no marriage Counseling facilities are available in India.4. Sickle Cell Anemia is more prevalent in Vidarbha region of Maharashtra,it’s more prevalentin backward communities particularly in schedule caste,schedule tribes and other backwardcommunities. In eastern part of Vidarbha region i.e. Chandrapur,Ghadchiroli, Wardha,Nagpur and Amravati are the districts where more no.of cases are found.5. Chronic Anemia(Hb level around or <8gm/dl),painful crisis due tovasoocclusion and Acute Chest Syndrome are the common symptoms maylead to organ damage, susceptibility to infection, growth failure,etc.Manifestation of Sickle Cell Anemia are unpredictable and variabletherefore there are no fix guidelines and specific drugs are available formanagement and treatment of crisis.6. Though the disease is very common it is neglected and comparativelyless medical literature is available. There is no National Policy in availablein India for treatment and prevention of disease.7. Use of Hydroxyurea which has shown good result in crisis is less usedotherwise crisis is treated symptomatically.8. There are many factors which precipitate the crisis in Sickle Cell Anemiaso to study these factors is the main aim of this study and to educatecounsel and prevention is also a part of this study