Introduction: During the past decade metronidazole has emerged as highly effective agent, both for treating and preventing a wide variety of anerobic bacterial disease. It is a stable and readily available drug that rapidly achieves theraputic concentration in virtually all body tissue and fluids after rectal, oral and intravenous administration. Methodology: This work essentially consists of management of tetanus cases admitted to Government General Hospital  and compare the results of cases treeated with I.V. Metronidazole and pencillin Results: In penicillin group 90% deaths occurred whereas in Metronidazole group 47% deaths occurred among severe cases. In penicillin group  30% deaths occurred whereas in  Metronidazole group  28% deaths occurred among mild cases. Conclusion: Duration of stay in hospital in metronidazole group is shorter compared to penicillin group.