Home
Editorial Board
Submit article
Join as Reviewer/Editor
List of Reviewer
Indexing Information
Most popular articles
Open Access
Purchase Single Articles
Archive
Current Issue
Recommend this journal to your library
Advertiser
Accepted Articles
Search Articles
Email Alerts
Subscribe
FAQ
Contact Us
New Indian Journal of Surgery

Volume  3, Issue 3, July - September 2012, Pages 254-254

 

Shortcommunication

Hemophagocytic Lymphohistiocytosis: A Life Threatening Rare Entity
Najmal Nazeer, V. Bafna, V. Kalrao
Bharati Vidyapeeth Deemed University Medical College, Pune, India
Choose an option to locate / access this Article:
Check if you have access through your login credentials.             |
|


Abstract

 Hemophagocytic Lymphohistiocytosis (HLH) is a rare disorderofthe immune system,affecting macrophages that grow abnormally and accumulate in body organs which include liver, spleen, bone marrow, CNS and skin. There are 2 types of HLH: 

Primary: An inherited condition where there is a genetic mutation in:
• Perforin (PRF-1)
• Gene encoding Munc 13-4 protein which alters the NK & Tcell function.
Secondary: Triggered by infections (viral, bacterial, fungal), autoimmune disorders, primary immune deficiencies or cancer.


Corresponding Author : Najmal Nazeer