Leprosy continues to be a significant problem in certain pockets of developing countries. India is the leading responsible country for the world-prevalence of leprosy. Globally, 60% of the estimated cases are contributed by India. MDT (Multi-drug therapy), which is the treatment recommended by WHO, cures patients and interrupts transmission of leprosy and prevents disabilities. However, MDT has been associated with problems like undesirable side- effects, poor compliance, drug resistance and high relapse rates. Considering the number of cases contributed by India, it has serious implications. Thus, present study was undertaken to analyse the prescribing pattern and drug-related problems in patients with Hansen’s disease.