Type 2 diabetes mellitus(T2DM) has attained a state of epidemic of late. It is known to predispose many a number of systemic complications, starting from myocardial infarction till candidial infections and still the count goes on. A lot of drugs are in use and also in the process of making to control diabetes. Incretin and its analogues are a recent advancement. Artificial sweeteners are also used to control blood sugars. Could they have an impact on the level of incretins as well?