WHO progress report- 2011 on HIV/AIDS in South East Asia Region reveals that 34 million people were living globally with HIV , and 2.4 million were in India. National prevalence rate was found to be 0.31% and 0.48% in women attending Antenatal clinics. The Indian subcontinent is classified as an intermediate Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone. India has 43 million HBV positive and 15 million HCV positive persons. The risk of transfusion transmission of these viruses may be alarming due to high seroprevalence of HIV, anti-HCV, and HBsAg (0.5%, 0.4%, and 1.4%, respectively) among blood donors. Blood is one of the major sources of transmission of hepatitis B, hepatitis C, HIV, syphilis, and many other diseases. In July 1989, mandatory screening of blood and blood products for HIV antibodies was initiated by Indian National AIDS Control Origination (NACO). Testing for human immunodeficiency virus (HIV), syphilis, and hepatitis B surface antigen (HBsAg) in pregnancy and labor is medically indicated to prevent vertical transmission. Prevalence of these infections among the antenatal population may be a reliable indicator of general population prevalence and determinant of vaccination policy . Successful interventions to prevent vertical transmission linked to intrapartum rapid testing have been demonstrated in a variety of limited resource settings Keeping in mind the grave consequences of these infections and to restrain the transmission to minimum, it is very important to remain vigilant about the possible spread. Routine surveillance, screening of blood donors, strengthening the services for treatment of sexually transmitted diseases, preventing mother to child transmission of blood borne pathogens has been put forward by NACO for strict implementation.