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New Indian Journal of Surgery

Volume  3, Issue 3, July - September 2012, Pages 185-185

 

Shortcommunication

The Neurotrophic Effect of Tacrolimus (FK506) on Pyramidal Cells of Brain Cortex Following Global Ischemic/Reperfusion in Wistar Rat
Ghazal Ansarian, Zahra-Nadia Sharifi, Shabnam Movassaghi, Hamed Shafaroodi, Nooshin Panahi Khezri
Pharmaceutical Science Branch, Islamic Azad University, Tehran, Iran
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Abstract

  Cerebral ischemia is known as a major problem in the world. Transient global cerebral ischemia causes loss of pyramidal cells of brain cortex following global ischemic/reperfusion. Recently, using immunophilin ligands has been considered as a potential and appropriate strategy for neuroprotection. Since it was observed that tacrolimus (FK506), a useful immunosuppressant used in organ transplantation, provides neuroprotection and prevents neuronal damage,the importance of immunophilins in the development of neuroprotectors has emerged.
 


Corresponding Author : Ghazal Ansarian