Aim: To compare the efficacy of autologous platelet-rich fibrin (PRF) over moist sterile saline/ povidone-iodine dressing in diabetic foot ulcers. Objective: To compare the mean reduction in ulcer area at the end of 4 weeks of dressings. Methodology: 60 diabetic patients with foot ulcers from the department of general surgery, general medicine, endocrinology, and cardiology were prospectively studied. Detailed clinical history was obtained, the ulcer was evaluated and the presence
of wound infection was assessed for all the patients. Patients were randomised into two groups of 30 patients each. While one group received PRF dressings, the other received saline/povidone-iodine
dressings. The wound healing was then compared in the two groups. The efficacy of platelet-rich fibrin dressing over moist saline/povidone-iodine dressings was assessed by comparing the percentage reduction of the ulcer area, at the end of four weeks, using chi-square test and A NOVA test. Results: It was found that there was a better reduction in the area of the ulcer at the end of four weeks in patients who received platelet-rich fibrin dressings than in moist saline/povidone-iodine
dressings. Conclusion: PRF dressing was superior to moist saline/povidone-iodine dressings.
Keywords: Diabetes; Foot ulcer; PRF.