Background of study: According to the WHO, more than 800,000 people die by suicide a year, making it the principal cause of death among people 1 5-29 years old. An annual global age-standardized suicide rate of 11.4 per 100 000 populations in which 15.0 are males and 8.0 are females. Objectives of the study: To assess the levels of knowledge regarding risk factors and prevention of suicide among the adolescents. To evaluate the effectiveness of structured teaching programme on knowledge regarding risk factors and prevention of suicide among adolescents. To find significant association between the pre-test knowledge score with selected socio-demographic variables. Methodology: One group pre-test and post-test design was used for this study. The independent variable in this study is planned teaching programme on knowledge regarding risk factors and prevention of suicide among adolescents. The study was conducted at selected college at Solapur. Sample includes 60 adolescents who fulfils the inclusion criteria were selected by non-probability purposive sampling technique. Result: The pre-test mean score is 13.41±2.64 which is 31.92% and post-test mean score is 17.58±3.08 which is 73.25% with a difference of 41.33%.The paired’ test value is 7.35 which is significantly higher than the table value of 2.0009 at p≤0.05 level. Thus the structured teaching programme is effective in improving the knowledge regarding Risk factors and Prevention of suicide among Adolescents. There was no significant association found between the knowledge regarding Risk factors and Preventive measures of suicidal behavior among adolescents with their age, gender, and type of family, history of suicide or suicidal attempt, history of mental illness, history of substance abuse and source of information but there is significant association with area of residence at p≤0.05 level. Conclusion: This study intervention would help the adolescent to run healthy life without any distress, reduce the risk of suicidal behavior and also encourage them also to help those who have suicidal risk in the public or among friends. Keywords: Structured Teaching Programme; Prevention of Suicide.