Objective: To discover the clinical risk factors that may affect the outcome, over a 6-year period of CTB at King Abdul Aziz University Hospital (KAUH), Jeddah, Design: Retrospective study From January 2005 to December 2010. Results: A total of 78 cases were reviewed. 34 (43.59%) males and 44 (56.41%) females. Factors that may lead to poor prognosis were: old age (p<.047), headache (p<.025), history of weakness (p<.005), classic TB symptoms (p<.001), history of contact with a TB patient (p<.006), HIV (p<.001), elevated ESR (p<.001) and altered mental status (p<.001). Conclusion: CTB presentation is usually with headache. Clinical risk factors are: headache, weakness, ESR and others. Patients with those risk factors should receive full medical treatment.

Keywords: Tuberculoma, Meningitis, Tuberculosis, Saudi Arabia,  Jeddah