Background: Annually around 100 million cases of dengue fever and half a million cases of Dengue haemorrhagic fever occurs worldwide. Early recognition and prompt initiation of treatment and platelet transfusion in indicated cases are imperative if disease related morbidity and mortality are to be restricted. Aim: To evaluate the role of platelet count in predicting outcome in dengue patients, to observe the number of serologically dengue positive patients requiring platelet transfusion and observe its outcome. Materials and Methods: The present study was conducted in the Department of Pathology, Sree Mookambika Institute of medical Sciences, Kulasekharam, Kanyakumari District, Tamilnadu during a period of three years from 2013 to 2015. In this study fifty dengue positive cases were taken from the Department of General Medicine, Sree Mookambika Institute of Medical Sciences, Kulasekharam. Results: In this study among fifty patients the patients where platelet transfusion was indicated were 43(86%). Thrombocytopenia was observed in 43(86%) 2(4%) patients had platelet transfusion on the day of admission, 26(52%) on the first day after admission, 8(26%) on the second day after admission and 7(14%) on the third day after admission. In this study 27(54%) of the patients were infused 1-2 units of platelets, 5(10%) of patients were given 3-4 units of platelets, 8(16%) of patients were given 5-6 units, 2(4%) were given 7-8 units of platelets and 1(2%) was given 9-10 units. In this study of 50 patients, 43 were transfused platelets. 3(6.98%) took 2 days for platelet count to return to normal levels, 23(53.49%) took 3 days, 9(20.93%) took 4 days, 3(6.98%) took 5 days and 5(11.63%) took 6 days. Conclusion: Platelet transfusion was initiated in patients with moderate to severe thrombocytopenia. The patients had a smooth and rapid recovery with no adverse outcomes related to the transfusion. All patients in our study group made a complete recovery during the hospital stay within the follow up period. Early suspicion, screening, diagnosis and prompt management of Dengue fever will effectively lower any fatality related to this dreaded illness. 

Keywords: Dengue; Thrombocytopenia; Platelet Transfusion; Fever; Haemorrhage.