Context: Breast cancer is the most common malignancy in
females. Advancement in cancer management had lead to early
detection and treatment of disease. Recently Immunohistochemistry
plays an vital role in the classification of breast cancer. Estrogen
Receptor/Progesterone Receptor and Human epidermal growth
factor receptor/neu (Her2/neu) status provides prognostic and
therapeutic information. Aims: This study is done to find the
association between Her2/neu by immunohistochemistry and
various clinicopathological factors in breast cancer. Study design: The
present study is a cross sectional study. Material and Methods: Forty
patients who were diagnosed to have carcinoma breast cancer patient
underwent Modified radical mastectomy were included in the study.
The surgical specimen were then evaluated histopathologically using
modified Bloom Richardsons grading and immunohistochemically
for Her2/neu markers. Results: In the present study most of the
cases were aged between 50–60 years. The mean age of presentation
was 52.4. The most common histological type were infiltrating ductal
carcinoma no special type, constituting 35 (87.5%). Grade II tumours
were seen in 57.5%. Her2 was positive in 16 cases (40%), and it
was negative in 26 (60%). Among the positive cases 14 cases were
of Grade III. Lymphovascular involvement was seen in 15 cases.
Conclusion: This study emphasize the need of Her2/neu in routine
histopathological report in breast cancers. Her2 positivity increased
as the tumour Grade increases and also had increased lymphnode
involvement, lymphovascular invasion with poor prognosis.
Keywords: Breast cancer; Human Epidermal Growth Factor
Receptor2/neu; Tumour grade.