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Indian Journal of Pathology: Research and Practice

Volume  9, Issue 1 (Part-I), January-April 2020, Pages 57-63
 

Original Article

Histopathologic Spectrum of Neoplasms of the Uterine Corpus in a Tertiary Care Hospital

Prathyusha Nakka1, Inuganti Venkata Renuka2, Amulya Boddapati3, Ramya Potti4, Garima Bontha5

1IIIrd year Post Graduate, 2Professor and HOD, 3Assistant Professor, 4Assistant Professor, 5IIIrd year Post Graduate, Dept. of Pathology, NRI Medical College, Chinnakakani, Guntur, Andhra Pradesh 522503, India.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9120.8

Abstract

Context: Tumors of the uterine corpus represent the second most common site for malignancy among the female genital system. These neoplasms are classified into epithelial, mesenchymal, mixed epithelial and mesenchymal, lymphoid, myeloid and secondary tumors. Aims: 1. To study the spectrum of lesions of the uterine corpus. 2. To study the incidence of benign and malignant tumors of uterine corpus. 3. To study the age preference among various types of benign and malignant tumors of the uterine corpus. Materials and methods: A prospective study was done in the Department of Pathology, NRI Medical College from June 2018 to July 2019. All the specimens received were fixed in 10% formalin and routinely processed. Sections were made from paraffin-embedded blocks and stained with hemotoxylin and eosin. Statistical analysis used: Percentages. Results: In 439 hysterectomy cases, 190 cases had uterine corpus neoplasms, of which 155 (81.57%) were benign neoplasms, and 35 (18.42%) were malignant. In the benign neoplasms, 153 were leiomyomata, and two were adenomyomata with commonest age group at presentation being 4th decade. In the malignant neoplasms, the most common tumor was welldifferentiated endometrioid carcinoma with 5th decade being the commonest age group of presentation. Four cases of malignancy within an endometrial polyp were noted along with some rare malignancies like clear cell carcinoma (2.85%), serous carcinoma (5.71%), leiomyosarcoma (5.71%), high-grade endometrial stromal sarcoma (2.85%), carcinosarcoma (5.71%) and adenosarcoma (2.85%). Conclusions: In our study, benign pathologies were more common than their malignant counterparts in the uterine corpus. In benign neoplasmsleiomyoma was the most common and in malignant neoplasms well-differentiated endometrioid carcinoma predominated.

Keywords: Hysterectomy; Uterine corpus; Leiomyomata; Endometrioid carcinoma.


Corresponding Author : Inuganti Venkata Renuka